Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes—from fundamental cell surface binding,
intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find
this book to be conceptually rich, timely, and useful.
Readership: Cell biologists, biophysicists, biochemists, pharmacologists, immunologists, molecular biologists, chemical engineers, biomedical engineers, biochemical engineers.
Douglas A. Lauffenburger, Alumni Professor of Chemical Engineering and Cell & Structural Biology, University of Illinois, Urbana, and Jennifer J. Linderman, Assistant Professor of Chemical Engineering, University of Michigan, Ann Arbor
""Bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modelling approach combines with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. . . . conceptually rich, timely, and useful." —Biology Digest"
""Draws on mathematical and cellular bioengineering concepts to lay a detailed foundation in three of the major conceptual areas of receptor biology. . . . the conceptual framework in quantitative cellular biology provided here is a welcome one." —Science"
""Writing with emthusiasm but with care, they go a long way toward their stated goal of bridging the gap [between chemical engineers and cell biologists. Even those such as biophysical chemists who already consider themselves part of the bridge will have a lot to gain from the book. This is a strong contribution to a surging interdisciplinary effort." —Barbara Baird, Cornell University, Nature"
""This lucid text provides a much-needed rational guide. It is a unique contribution to the field of receptor biology and cellular engineering because it is equally accessible — and useful — to the chemical engineer and the molecular or cell biologist. . . . presents a thorough, yet comprehensible, introduction to the mathematical tools and physical basis needed for quantitative analysis of all the major classes of receptor-mediated phenomena. . . . an essential reference for engineers working in such diverse fields as tissues engineering, drug design and delivery, and cell culture. . . . this book will have an impact far beyond the chemical engineering community — it may change the way
receptor biologists view their work." —Linda G. Cima, Massachusetts Inst. of Tech., AIChE Journal"
""An excellent introduction to integrative cell biology. A useful feature is that the reader is not involved in the details of mathematical methods of solutions of differential equations: the basic equations are presented and the physical and chemical meanings of terms in the equations are discussed, and then the solutions are presented, often in graphical form. Cited references are abundant, and...the reader can obtain the details from the literature....For use in a classroom setting, the 150-200 references at the chapter ends...provide plenty of sources for problem material. This reviewer recommends this book to those looking for the future directions in biomedical science; it will be
found enlightening by biological and physical scientists and engineers." —Journal of the American Chemical Society"
""This wonderfully well written book is an essential addition to the library of any mathematical biologist interested in mathematically modeling cell function, as well as to members of many other fields who are interested in quantifying cell behavior. The book is well organized...intended readership is very broad, and the book is strong in many areas. Other positive features of the book which must be mentioned are its attention to experimental aspects of receptor biology, its writing and its organization. This book is a critical addition to your library if you have any interest in the quantitative aspects of cell function."—Daniel A. Hammer"
"a very comprehensive overview of the biology of cell surface receptors ... the book is highly recommended for cell biologists working in the receptor field, in particular those approaching mathematical models for ligand/receptor interactions and trafficking." - Søren K. Moestrup, FEBS Letters 398 (1996)
1: Cell Surface Receptor/Ligand Binding Fundamentals
2: Receptor/Ligand Trafficking
3: Physical Aspects of Receptor/Ligand Binding and Trafficking Processes
4: Signal Transduction
5: Receptor-Mediated Cell Behavior
6: Future Directions