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Brain Development
Normal Processes and the Effects of Alcohol and Nicotine
Edited by Michael W. Miller
420 pages
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47 halftones, 19 line illustrations
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254x175mm
978-0-19-518313-9
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Hardback
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25 May 2006
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- Includes unique coverage - normal neural development, effects of alcohol and effects of nicotine
- Highlights the clinical importance of nicotine and alcohol
- Alcohol is the most thoroughly understood developmental toxin, and this book is the most detailed description of its effects on the developing brain
- Developmental consequences of nicotine are poorly understood but this book sheds light on them
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common
neurotoxin is nicotine, and it is discussed in this book for three reasons: (1) the number of adolescents who smoke cigarettes is rising in some populations; (2) prenatal exposure to nicotine affects neurotransmitter systems that are critical for normal brain development and cognition; and (3) prenatal exposure to nicotine is often accompanied by prenatal exposure to alcohol.
The mature brain is the culmination of an orderly sequence of basic ontogenetic processes - cell proliferation, migration, differentiation, and death. Neural stem cells and progenitors proliferate in discreet sites; then, young neurons migrate long distances to their residences where they form neural networks. During this sequence many immature cells die, presumably eliminating unsuitable or
non-competitive cells. Each process is regulated by genetic and environmental factors. When this regulation goes awry, a dysmorphic and dysfunctinoal brain results. Though this can be tragic in clinical settings, in experimental contexts it provides keen insight into normal brain development.Readership: Neuroscientists, developmental biologists, teratologists, pharmacologists, toxicologists, neurologists, neuropsychologists, students and trainees.
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Edited by Michael W. Miller, Professor and Chair, Department of Neuroscience & Physiology, SUNY-Upstate Medical University, Syracuse, USA
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"...a very detailed and in-depth look at the topic...an excellent book that will be useful to many readers, including pediatricians, toxicologist, substance abuse specialists, researchers, and many others." - Doody's Notes
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1: Michael W. Miller: Models of Neurotoxicity Provide Insight into Normal Development
Part I - Normal Development
2: Bernhard Suter and Pradeep G. Bhide: Cell Proliferation
3: Huaiyu Hu: Neuronal Migration
4: C. David Mintz, Iddil H. Bekirov, Tonya R. Anderson, and Deanna L. Benson: Neuronal Differentiation: From Axons to Synapses
5: Stevens K. Rehen and Jerold J.M. Chun: Cell Death
6: Sandra M. Mooney and George I. Henderson: Intracellular Pathways of Neuronal Death
7: Barbara L. Finlay, Jeremy C. Yost and Desmond T. Cheung: Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience
Part II - Ethanol-Affected Development
8: Claire D. Coles: Prenatal Alcohol Exposure and Human Development
9: Susanna L. Fryer, Christie L. McGee, Andrea D. Spadoni, and Edward P. Riley: Influence of Alcohol on the Structure of the Developing Human Brain
10: Joanna H. Sliwowska, Xingqi Zhang, and Joanne Weinberg: Prenatal Ethanol Exposure and Fetal Programming: Implications for Endocrine and Immune Development and Long-Term Health
11: Michael W. Miller: Early Exposure to Ethanol Affects the Proliferation of Neuronal Precursors
12: W. Michael Zawada and Mita Das: Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
13: Julie A. Siegenthaler and Michael W. Miller: Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
14: Tara A. Lindsley: Effects of Ethanol on Mechanisms Regulating Neuronal Process Outgrowth
15: Michael W. Miller, Marla B. Bruns and Paula L. Hoffman: Neuronal Survival Is Compromised by Ethanol: Extracellular Mediators
16: Sandra M. Mooney, Michael W. Miller and George I. Henderson: Intracellular Events in Neuronal Death Targeted by Ethanol
17: Susan M. Smith and Katherine A. Debelak-Kragtorp: Neural Crest and Developmental Exposure to Ethanol
18: Consuelo Guerri, Gemma Rubert, and Maria Pasqual: Glial Targets of Developmental Exposure to Ethanol
Part III - Nicotine-Affected Development
19: Jennifer A. Willford, Nancy L. Day, and Marie D. Cornelius: Tobacco use During Pregnancy: Epidemiology and Effects on Offspring
20: Brenda M. Elliott and Neil E. Grunberg: Prenatal Nicotine Exposure and Animal Behavior
21: Huibert D. Mansvelder and Lorna W. Role: Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
22: Kurt F. Hauser, Nazira El-Hage, Shreya Buch, Gregory N. Barnes, Henrietta S. Bada, and James R. Pauly: Neural Precursors as Preferential Targets for Drug Abuse: Long Term Consequences and Latent Susceptibility to CNS Disorders
23: Frances M. Leslie, Layla Azam, Kathy Gallardo, Kathryn O'Leary, Ryan Franke, and Shahrdad Lotfipour: Nicotinic Receptor Regulation of Developing Catecholamine Systems
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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