An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication, and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Edited by Dhavendra Kumar, Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK
"I can see it having a place in the libraries of hospitals and clinical departments alongside other classic textbooks." - Human Genetics
SECTION 1: GENERAL GENOMICS 1: From Genes to Genome - a Historical Perspective 2: The Human Genome - Structure and Organization 3: Human Functional Genomics and Proteomics 4: Epigenomics and Human Disease 5: Genomic Perspectives of Human Development 6: Genetic and Genomic Approaches to Taxonomy of Human Diseases 7: Genomic Technologies 8: Nutritional Genomics 9: Pharmacogenomics: Drug Development, Drug Response and Precision Medicines SECTION 2: CLINICAL GENOMICS 10: Clinical Medicine in the Genome Era - An Introduction 11: Complex Cardiovascular Disorders 12: Diabetes Mellitus and Obesity 13: Chronic Renal Disease 14: Haemostasis and Thrombosis 15: Disorders of Platelets 16: Applications in Critical Care Medicine 17: Seizure Disorders 18: Neurodegenerative Disorders: Tauopathies and Synucleinopathies 19: Neuropsychiaric Diseases I: Schizophrenia 20: Neuropsychiaric Diseases II: Mood Disorders 21: Asthma and Chronic Obstructive Pulmonary Disease 22: Inflammatory Bowel Disease 23: Cancer Genomics: Mechanisms, Diagnosis and Therapeutic Implications 24: Hematological Malignancies: The Paradigm of Acute Myeloid Leukemia 25: Infectious Diseases: Susceptibility, Resistance, Response, and Anti-Microbial Therapy 26: Chronic Inflammatory Disorders 27: Immunological Disorders 28: Applications in Clinical Pediatrics 29: Learning and Behavioural Disorders 30: Complex Ophthalmic Disorders 31: Applications in Audiological Medicine 32: Complex Skin Diseases I: Psoriasis 33: Complex Skin Diseases II: Atopic Dermatitis 34: Complex Skin Diseases III: Diseases of the Epidermis and Appendages, Skin Pigmentation and Skin Cancer 35: Osteoporosis and Related Disorders 36: Applications in Obstetrics & Gynaecology and Reproductive Medicine 37: Stem Cell Genomics, Cell-based Therapy and Regenerative Medicine SECTION 3: HEALTH GENOMICS 38: Genomics and Global Health 39: Genetic Testing and Genomic Screening 40: Ethical Issues in Human Genomics 41: The Regulation of Human Genomics Research
