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Macromolecular Crystallography
conventional and high-throughput methods
Edited by Mark R. Sanderson and Jane V. Skelly
304 pages
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Numerous halftones and line figures
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246x189mm
978-0-19-852097-9
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Hardback
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23 August 2007
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- The first practical reference book that covers both conventional and high-throughput methods, ranging from cloning and crystallisation to refinement and modelling
- Chapters written by an international team of experts from the field of macromolecular crystallography
- A rapidly expanding and developing field in both academia and industry, mainly due to the recent explosion in structural genome research.
- Includes applications such as drug design.
Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs.
The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing
field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice.
This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and
high-throughput macromolecular crystallography.Readership: Research scientists, graduate students and professionals currently working with, or interested in working in the field of conventional and high-throughput macromolecular crystallography.
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Edited by Mark R. Sanderson, Randall Division of Cell and Molecular Biophysics, King's College London, UK., and Jane V. Skelly, Medway School of Science, University of Greenwich, UK. Contributors:
Batuwangala
Skelly
Owens
Nettleship
Berrow
Stuart
Stammers
Chayen
Abdel-Meguid
Jeruzalmi
Sanderson
Delarue
Murthy
Weeks
Furey
Abrahams
Morris
Perrakis
Lamzin
Wasserman
Smith
D'Amico
Koss
Burley
Carson
Masquida
Francois
Werner
Westhof
Sohi
Laponogov
Fry
Abrescia
Stuart
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"it is more than successful, and most, if not all, who dip into it will be rewarded by learning things they did not know, or possibly had forgotten...[..] a book that will surely find its place in every crystallographic lab whether protein or macromolecular." - Lindsay Sawyer, Crystallography News
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1: Skelly, Sohi & Batuwangala: Classical Cloning, Expression and Purification
2: Owens, Nettleship, Berrow, Stuart & Stammers: High-Throughput Cloning, Expression and Purification
3: Chayen: Automation of Non-Conventional Crystallization Techniques for Screening and Optimisation
4: Abdel-Meguid, Jeruzalmi & Sanderson: First Analysis of Macromolecular Crystals
5: Sanderson: In-House Macromolecular Data Collection
6: Abdel-Meguid: Solving the Phase Problem Using Isomorphous Replacement
7: Delarue: Molecular Replacement Techniques for High-Throughput Structure Determination
8: Murthy: MAD Phasing
9: Weeks & Furey: Application of Direct Methods to Macromolecular Structure Solution
10: Abrahams: Phase Refinement through Density Modification
11: Morris, Perrakis & Lamzin: Getting a Macromolecular Model: Model Building, Refinement and Validation
12: Wasserman, Smith, D'Amico, Koss, Morisco, and Burley: High-Throughput Crystallographic Data Collection at Synchrotrons
13: Carson: Electron Density Fitting and Structure Validation
14: Masquida, Francois, Werner & Westhof: RNA Crystallogenesis
15: Sohi & Laponogov: Crystallography in the Study of Protein-DNA Interaction
16: Fry, Abrescia & Stuart: Virus Crystallography
17: Abdel-Meguid: Macromolecular Crystallography in Drug Design
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