Readership: This book will be invaluable to students of health economics studying economic assessment methods; investigators working on economic analysis in clinical trials will find practical advice concerning the design and analysis of such studies; those in industry and government who fund clinical trials, and are interested in the claims regarding cost-effectiveness, will find useful information to determine whether the proposed studies are methodologically sound.
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"...a straight-forward guide to a not-so-straightforward topic. The book illustrates the difference between 'hard' sciences like chemistry with 'one answer' and 'soft' sciences like economics with 'many answers.' It is essential reading for anyone who wants to know a) how to find a good, maybe even the right, answer, b) how to find the answer that meets the marketing department's needs, and c) how to find the holes in the answer you have been given to get a product into your formulary. Economic evaluation in clinical trials is clearly an area where knowledge is power." - Journal of Clinical Research Best Practices
1: Introduction 2: Designing economic evaluations in clinical trials 3: Valuing medical service use 4: Assessing quality-adjusted life years 5: Analyzing cost 6: Analyzing censored cost 7: Comparing cost and effect: point estimates for cost-effectiveness ratios and net monetary benefit 8: Understanding sampling uncertainty: the concepts 9: Sampling uncertainty: calculation, sample size and power, and decision criteria 10: Evaluating transferability of the results from trials 11: Relevance of trial-based economic analyses
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