Introduction to the Cellular and Molecular Biology of Cancer

• Great breadth of coverage in one volume: covers all aspects of cancer, in a concise and affordable format
• Provides a comprehensive introduction to the initiation, development, and treatment of cancer
• Chapter are written by experts in each field, giving a state-of-the-art summary of each topic
• Extensive references provide links to all the relevant literature, facilitating further study

New to this edition

• This edition has undergone major changes to reflect rapid progress and new developments. Eight new chapters have been added, including coverage of DNA repair, epigenetic events, the cell cycle, cell immortalisation, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. All the material from the previous edition has been extensively revised and new authors have contributed to some chapters.

Readership: Undergraduates and postgraduates taking cellular and molecular biology courses; medical students; oncologists.

Margaret Knowles, Cancer Research UK Clinical Centre, Leeds, UK, and Peter Selby, National Cancer Research Network, Leeds, UK

Review(s) from previous edition

"This edition is highly recommended to students of cancer, whether they be medical or non-medical scientists, and will take its readers to the leading edge of cancer research ... admirable book. - The Bulletin of the Royal College of Pathologists

"Successive editions of this book have mirrored developments in cancer research and this new edition continues to provide a short but comprehensive introduction to the initiation, development and treatment of cancer." - ASLIB Book Guide

"The first two editions were good: now it is excellent ... everything is covered and relevant citations are given. Not only are important basic clinical and pathological issues covered, but so too are all the important areas of tumour biology and the molecular processes and genetics relevant to cancer ... I consider this an invaluable book ... I intend to advise all my new graduate students and post docs to buy, read, and study a copy ... masterfully edited and well-illustrated text. This book is great! If you are interested in cancer, buy a copy!" - Peter A. Hall, Journal of Pathology

"This is an excellent book ... As one who teaches cancer genetics among other things, I greatly welcome a source to which one can recommend students ... A fascinating read for everyone with an interest (morbid or not) in the subject." - Simon Baumberg, Univ. of Leeds, SGM Quarterly

"This book will be much appreciated by newcomers to cancer biology and will provide a concise and thought-provoking review for experts in the field." - Stanley Zucker, The Quarterly Review of Biology, Vol 82 June 2007

"This is a superb introduction to cancer studies for clinicians and is difficult to fault ... this must be a bargain hard to beat. I strongly recommend this text for all involved in cancer studies and the care of patients with cancer." - Crispian Scully, Oral Oncology

1: L.M. Franks and Margaret A. Knowles: What is cancer?
2: Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key: The causes of cancer
3: D. Timothy Bishop: Inherited susceptibility to cancer
4: Beate Köberle, John P. Wittschieben, and Richard D. Wood: DNA repair and cancer
5: Jonathan C. Cheng and Peter A. Jones: Epigenetic events in cancer
6: Denise Sheer and Janet Shipley: Molecular cytogenetics of cancer
7: Margaret A. Knowles: Oncogenes
8: Sonia Lain and David P. Lane: Tumour suppressor genes
9: Chris J. Norbury: The cancer cell cycle
10: Robert F. Newbold: Cellular immortalization and telomerase activation in cancer
11: Sally A. Prigent: Growth factors and their signalling pathways in cancer
12: Dean A. Fennell: Apoptosis: molecular physiology and significance for cancer therapeutics
13: Paul Farrell: Mechanisms of viral carcinogenesis
14: Peter W. Szlosarek and Frances R. Balkwill: Cytokines and cancer
15: Charlotte L. Bevan: Hormones and cancer
16: Ian Hart: The spread of tumours
17: K.Tahtis and R.Bicknell: Angiogenesis
18: Mel Greaves: Stem cells, heamopoiesis, and leukaemia
19: Jos Jonkers and Anton Berns: Animal models of cancer
20: Peter C. L. Beverley: The immunology of cancer
21: Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine: The molecular pathology of cancer
22: Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks: From transcriptome to proteome
23: Ian S. Fentiman: Local treatment of cancer
24: D.R. Camidge and D.I. Jodrell: Chemotherapy
25: Anne Kiltie: Radiotherapy and molecular radiotherapy
26: T. Geldart, M.J. Glennie, and P.W.M. Johnson: Monoclonal antibodies and therapy
27: Andrew M. Jackson and Joanne Porte: Immunotherapy of cancer
28: John David Chester: Cancer gene therapy
29: Peter Sasieni and Jack Cuzick: Screening
30: Peter Selby and Margaret A Knowles: Conclusions and prospects