Evolution in Health and Disease

• Describes how evolutionary thinking gives insight into human health and disease, establishing evolutionary biology as an essential basic science for medicine
• Integrates contributions from the leading researchers in the field to describe the latest research in evolutionary medicine
• Suggests exciting possibilities for future treatment and research
• Explains why we grow old, and how to stay healthy as we age

New to this edition

• The text is fully revised - 95% of the material is new

Readership: An advanced, research level text suitable for graduate level students and researchers in the fields of evolutionary (Darwinian) medicine, evolutionary biology, anthropology, developmental biology and genetics. The book will also be of relevance and use to medical researchers, medical and biological educators, and doctors.

Edited by Stephen C. Stearns, Yale University, and Jacob C. Koella, Imperial College London

"This book is a veritable treasure trove...The book is written in an extremely clear, mostly nontechnical style." - Lab Times

"The book should be a welcome addition to the shelves of academics and students in the biological sciences, as well as medical practitioners for whom it was primarily intended." - Jerzy M. Behnke Parasites & Vectors

"...this book will stimulate fresh thinking and new approaches to traditional medical problems" - The New England Journal of Medicine

"The chapters are well-organized and refreshingly free of jargon, with good flow across the diverse range of topics." - American Journal of Human Biology

"This splendid book, will not only delight biologists (both established and apprentice) but also help medical students to appreciate biological issues underlying their future craft." - Biologist magazine

"This second edition is a welcome addition to the growing integration of the biomedical sciences. As an evolutionary biologist, I found myself grateful more than once that these well organized summary articles on so many disciplines connected to evolutionary biology and geomics could be found between only two covers!" - Lee F Greer, Doody's Notes

"The second edition of "Evolution in Health and Disease"(S.C. Stearns and J.C. Koella, editors) Provides a timely update that should help to further energize this interdisciplinary paradigm...[...] The coverage in "Evolution in health and disease" is broad, ranging from infectious to chronic disease and microbial genomics to life-history theory. "EVolution in health and disease"provides compelling evidence that and evolutionary perspective can lead to important and novel insights into issues relevant to human health." - Trends in Ecology and Evolution

Preface
Part I. Introduction
1: Stephen C. Stearns, Randolph M. Nesse, and David Haig: Introducing evolutionary thinking for medicine
Part II. The history and variation of human genes
2: Jean-François Guégan, Franck Prugnolle, and Frédéric Thomas: Global spatial patterns of infectious diseases and human evolution
3: Diddahally R. Govindaraju and Lynn B. Jorde: Medically relevant variation in the human genome
4: Michael Bamshad and Arno G. Motulsky: Health consequences of ecogenetic variation
5: Kenneth K. Kidd and Judith R. Kidd: Human genetic variation of medical significance
Part III. Natural selection and evolutionary conflicts
6: David Haig: Intimate relations: evolutionary conflicts of pregnancy and childhood
7: Richard G. Bribiescas and Peter T. Ellison: How hormones mediate tradeoffs in human health and disease
8: Dagan A. Loisel, Susan C. Alberts, and Carole Ober: Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk
9: Beverly I. Strassmann and Ruth Mace: Perspectives on human health and disease from evolutionary and behavioral ecology
Part IV. Pathogens: resistance, virulence, variation, and emergence
10: Carl T. Bergstrom and Michael Feldgarden: The ecology and evolution of antibiotic resistant bacteria
11: Andrew F. Read and Margaret J. Mackinnon: Pathogen evolution in a vaccinated world
12: Dieter Ebert and James J. Bull: The evolution and expression of virulence
13: Paul M. Sharp, Elizabeth Bailes, and Louise V. Wain: Evolutionary origins of diversity in human viruses
14: Daniel Dykhuizen and Awdhesh Kalia: The population structure of pathogenic bacteria
15: Julian Parkhill: Whole-genome analysis of pathogen evolution
16: Mark Woolhouse and Rustom Antia: Emergence of new infectious diseases
17: Jacob C. Koella and Paul Turner: Evolution of parasites
Part V. Noninfectious and degenerative disease
18: Martin Ackermann and Scott D. Pletcher: Evolutionary biology as a foundation for studying aging and aging-related disease
19: Christopher W. Kuzawa, Peter D. Gluckman, Mark A. Hanson, and Alan S. Beedle: Evolution, developmental plasticity, and metabolic disease
20: William R. Leonard: Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks
21: Mel Greaves: Cancer: evolutionary origins of vulnerability
22: Natalia L. Komarova and Dominik Wodarz: Cancer as a microevolutionary process
23: Steven N. Austad and Caleb E. Finch: The evolutionary context of human aging and degenerative disease
References
Index