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Macromolecular Crystallization and Crystal Perfection
Naomi E Chayen, John R Helliwell, and Edward H Snell
240 pages
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33 line illustrations, 31 halftones
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234x156mm
978-0-19-921325-2
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Hardback
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25 March 2010
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- Vital topic of key relevance in modern Life Sciences and Physical Sciences
- Wide readership in fast growing community
- Leading the reader from the fundamentals to the frontier and future prospects
- Interdisciplinary approach, including biological crystallgraphy, crystal growth, X-rays and neutrons
The crystallization of proteins and nucleic acids and/or their complexes has become more highly automated but is still often a trial and error based approach. In parallel, a number of X-ray diffraction based techniques have been developed which explain the physical reasons limiting the resulting crystallographic data and thus show how that data may be improved. Crystal growth is also pivotal in neutron crystallography, which establishes the hydrogen and hydration aspects. Thus this book is aimed at addressing the science behind obtaining the best and most complete structural data possible for biological
macromolecules, so that the detailed structural biology and chemistry of these important molecules emerge. Crystal imperfections such as twinning and lattice disorders, as well as multiple crystal situations, and their possible remedies, are also described. The small crystal frontier in micro-crystal crystallography, crystallites in powders and finally down to the proposed single molecule structure determination of X-ray lasers are covered. Overall this interdisciplinary book will interest crystal growers, X-ray and neutron physicists and the biological crystallographers, including graduate students.Readership: Researchers and PhD students in biochemistry, chemistry, molecular biology and physics. Crystal growers,
X-ray and neutron physicists and the biological crystallographers.
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Naomi E Chayen, Department of Biomolecular Medicine, Imperial College London, UK, John R Helliwell, School of Chemistry, University of Manchester, UK, and Edward H Snell, Hauptman-Woodward Institute, SUNY-Buffalo, USA.
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"A streamlined and logical summary of the sequence of procedures that a crystallographer needs to follow to obtain the structure of a protein of interest. The discussion greatly benefits from the authors' practical experience as protein crystallographers who have important structures under their belts." - The Journal of the American Chemical Society "According to the back cover of this excellent book, the target readership includes a diverse range of scientists. In my opinion, the authors have succeeded brilliantly in this aim; [...] the book provides not only the key basic facts, but also provides the reader with the essential information to investigate further. The book is timely and informative and certainly ought to be
widely read by a range of different scientists with interests in macromolecular structure." - Chemistry World
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I: INTRODUCTION AND OVERVIEW
1: Introduction
II: CRYSTALLIZATION
2: Crystallization Theory
3: Practical Methods of Crystallization
4: Screening
5: Optimization
6: Strategies when high quality crystals cannot be obtained
7: Membrane Proteins
8: Alternative Approaches
III: DIFFRACTION
9: Experimental Aspects
10: Analysis of the Molecular Short-Range Order
11: Analysis of the Long-Range Order
12: Macromolecular Crystals and Twinning
13: Other Macromolecular Crystal Diffraction Disorders
14: Degradation and Improvement of Crystal Perfection
15: Unusual Diffraction Geometries
16: Making the Most of Difficult Crystals
17: Protein Powders
18: Complementary Techniques
IV: THE FUTURE
19: The X-ray Laser and the Single Molecule
20: Overall Summary and Future Thoughts
Glossary of Abbreviations, Terms, and Symbols
References
Index
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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