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GTPases
Edited by Alan Hall
360 pages
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numerous figures
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246x189mm
978-0-19-963744-7
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Paperback
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20 January 2000
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- GTPases play key regulatory roles in many fundamental cellular processes.
- First time all GTPases covered in a single volume.
- Introduction to each major family of GTPases.
- Well illustrated with over 70 figures.
GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases: the G proteins, Ras, Rho, Rab, Arf, and Ran. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the versatility of GTPases to a much greater extent. The roles of two further families of GTPases in protein localization and protein tanslocation are discussed in chapter 8. Chapter 9 covers the huge amount of structural data accumulated for all families of GTPases and the
proteins with which they interact. The final chapter describes the modification of GTPases by numerous bacterial toxins. It is not surprising, therefore, that GTPases have become a centre of attention for those studying the control of proliferation, differentiation, cell polarity, cell movement and vesicle and protein trafficking. GTPases: Frontiers in Molecular Biology provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists and geneticists interested in these contemporary problems.Readership: Main: Postgraduates in cell signalling, membrane trafficking, nuclear export/import, actin cytoskeleton. Postgraduate/researchers in GTPase and inbacterial
pathogenesis. Other: Advanced biochemistry/cell biologists undergraduates.
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Edited by Alan Hall, MRC Laboratory for Molecular Biology, University College London Contributors:
Dr Klaus Aktories, Institut fur Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, Hermann Herder Strasse 5, D-79104 Freiburg, Germany; Dr Johannes L. Bos, Laboratory for Physiological Chemistry, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands; Dr Patrick J. Brennwald, Department of Cell Biology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA; Dr Amy Brownawell, Markey Center for Cell Signaling, University of Virginia, HSC Box 577, Charlottesville, VA 22908 USA; Dr Patrick J. Casey, Duke
University Medical Centre, Department of Pharmacology and Cancer Biology, Research Drive, C303 LSRC, Durham NC 27710-3686, USA; Dr Ruth N. Collins, Department of Molecular Medicine, Veterinary Medical College, Cornelll University, Ithaca, NY 14853; Dr Douglas M. Freymann, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA; Dr Jennifer L. Glick, Duke University Medical Centre, Department of Pharmacology and Cancer Biology, Research Drive, C303 LSRC, Durham NC 27710-3686, USA; Dr Alan Hall, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT; Dr Fred Hofmann, Institut fur Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, Hermann Herder Strasse 5,
D-79104 Freiburg, Germany; Dr Ian Macara, Markey Center for Cell Signaling University of Virginia, HSC Boxx 577, Charlottesville, VA 22908, USA; Dr Thomas E. Meigs, Duke University Medical Centre, Department of Pharmacology and Cancer Biology, Research Drive, C303 LSRC, Durham, NC 27710-3686, USA; Dr Susanne M. Mumby, Department of Pharmacology, University of Texas Southwestern Medical Centre, 5323 Harry Hines Blvd. Dallas TX 95235-9041, USA; Dr Anne J. Ridley, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT; Dr Michael G. Roth, Department of Biochemistry, University of Texas Southwestern Medical Centre, 5323 Harry Hines Blvd., Dallas, TX 75235-9038, USA; Dr Gudula Schmidt, Institut fur Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, Hermann
Herder Strasse 5, D-79104 Freiburg, Germany; Dr Peter Walter, Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California-San Francisco, 513 Parnassus Avenue-S964, San Francisco, CA 94143-0448, USA; Dr Katie Welch, Markey Centre for Cell Signaling, University of Virginia, HSC Box 577, Charlottesville, VA 22908, USA; Dr Alfred Wittinghofer, Max-Planck-Institut fur Molekular Physiologie, Abteilung Strukturelle Biologie, Rheinlanddamm 201, 44139 Dortmund, Germany
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""An extremely well laid out, comprehensive overview of the GTPase families ... an ideal reference for final year graduates" Cell Biology International"
""GTPases is a handy book ... will be a bible for people working on these aspects of signal transduction for many years to come" Journal of Cell Science"
""GTPases represents a successful attempt to gather in a handy, compact book a wealth of information about a field of rapid expansion ... GTPases will be of great utility not only for those interested in entering the field but also for the specialist" TRENDS in Biochemical Sciences"
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G proteins - I: Gs and Gi
G proteins - II, Gz, G12 and Gz
Ras
Rho
Rab
Arf
Ran
GTPases in protein translocation and protein elongation
The structure and function of molecular switches in three dimensions
GTPases and bacterial toxins
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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