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Combinatorial Chemistry
A Practical Approach
Edited by Hicham Fenniri
508 pages
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4 pp colour plates, numerous line figures
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246x189mm
978-0-19-963754-6
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Paperback
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05 October 2000
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- New design
- Written by several founders of combinatorial chemistry
- Practical guide to combinatorial chemistry with over 100 protocols
- Very well illustrated with over 135 tables, 125 figures some of which are colour
Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level
easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.Readership: Biomedical researchers wanting to use combinatorial techniques.
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Edited by Hicham Fenniri, H.C. Brown Laboratory of Chemistry, Purdue University, USA Contributors:
Arpad Furka, Linda K. Hamaker and Mark L. Peterson, Advanced ChemTech Inc., Louisville, USA; Gang Liu, Kit S. Lam, Arizona Cancer Centre, USA; Clemencia Pinilla, Jon R. Appel, Sylvie E. Blondelle, Colette T. Dooley, Jutta Eichler, Adel Nefzi, John M. Ostresh, Darcy B. Wilson and Richard A. Houghten, Torrey Pines Institute for Molecular Studies, USA; Roland Martin, National Institute of Neurological Disorders and Stroke, Bethesda, USA; Xizo-Yi Xia and K.C. Nicolaou, IRORI, California, USA; Holger Wenschuh, Lothar Germeroth, Jerini Bio Tools GmbH,
Berlin, Germany; Heinrich Gausepohl, Abimed Analysen-Technik GmbH, Germany; Mathias Ulbricht, Institute of Chemistry, GKSS Research Centre, Germany; Heike Matuschewski, Poly-An GmbH, Germany; A. Kramer, Rudolf Volkmer-Engert, Niklas Heine, Thomas Ast, Dirk Scharn, Jens Schneider-Mergener, Institute für Medizinische Immunologie, Berlin, Germany; Martin Winter University of Tuebingen, Institute of Organic Chemistry, Germany; Ralf Warrass, Institute de Biologie et Institut Pasteur de Lille, France.; William M. Bennett, Advanced Chem Tech, Inc. Kentucky, USA; Bing Yan, Axys Advanced Technologies, Inc., San Francisco, USA; Michael Shapiro, Jefferson Chin, Lina Liu, Novartis Pharmaceuticals Corporation, New Jersey, USA; Yen-Ho Chu and Zhiguang Yu, Department of Chemistry, Ohio State University,
USA; Ivar Ugi, Institute of Organic Chemistry and Biochemistry, Technische Universität München, Germany; Alexander Dömling, Fa. Morphochem, Martinsried, Germany; Dale L. Boger and Joel Goldberg, Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, USA; Dennis P. Curran, Sun-Young Kim, Zhiyong Luo Bruno Linclau, University of Pittsburgh, Department of Chemistry, USA; Sabine Hadida, CombiChem Inc., California, USA; Armido Studer, Laboratorium für Organische Chemie, Zurich, Switzerland; Mu He, Pimlico Court, Quail Ridge Development, Germany; Mats Larhed, Anders Hallberg, Department of Organic Pharmaceutical Chemistry, Uppsala University, Sweden; Ronald M. Kim and Jiang Chang, Merck Research Laboratories, New Jersey, USA; Tohru Sugawara and
David G. Cork, Takeda Chemical Industries Ltd., Japan; Erik Reddington, Jong-Sung Yu, Benny C. Chan, Anthony Sapienza, Guoying Chen, Thomas E. Mallouk The Pennsylvania State University, Department of Chemistry, USA; Bogdan Gurau, Rameshkrishnan Viswanathan, Renxuan Liu, Eugene S. Smotkin, Department of Chemical and Environmental Engineering, Illinois Institute of Technology, USA; S. Sarangapani, ICET Inc., Massachussettes, USA; Shu Kobayahsi, Graduate School of Pharmaceutical Sciences, The University of Tokyo Hongo, Japan; Marc L. Snapper and Amir Hoveyda, Merkert Chemistry Centre, Boston College, USA
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Synthesis of combinatorial libraries using the portioning-mixing procedure
One-bead-one-compound combinatorial library method
Synthesis and screening of positional scanning synthetic combinatorial libraries
High throughput combinatorial synthesis of discrete compounds in multimilligram quantities
Positionally addressable parallel synthesis on membrane supports
Resins and anchors for solid phase organic synthesis
Organic reactions on solid support - an overview
Analytical methods in combinatorial chemistry
Multi-component reactions (mcrs) of isocyanides and their chemical libraries
Multi-step solution phase combinatorial synthesis
Experimental techniques in fluorous synthesis
Dendrimer-supported combinatorial chemistry
Automated solution phase synthesis and its application in combinatorial chemistry
Combinatorial discovery and optimization of electrocatalysts
Combinatorial library synthesis using polymer-supported catalysts
Combinatorial Approaches to chiral catalysts discovery
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