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Protein Kinase Functions
Edited by James Woodgett
406 pages
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numerous line figures
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246x189mm
978-0-19-963770-6
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Paperback
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24 August 2000
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- Emphasis of the chapters is on the functions of protein kinases as part of a system
- All the major protein kinase pathways covered in one book
Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase
signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFß superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.Readership: Postgraduate biologists studying signal transduction pathways.
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Edited by James Woodgett, Ontario Cancer Institute, University of Toronto Contributors:
J Kyriakis, Diabetes Research Laboratories, USA; P. J. Coffer, Dept. of Pulmonary Diseases, University Hospital Utrecht, THE NETHERLANDS; K. L. Gould, Howard Hughes Medical Institute Vanderbilt University School of Medicine, USA; S. Plyte, Pharmacia and Upjohn, ITALY; L Attisano, Dept. of Anatomy & Cell Biology, University of Toronto; D Barber, Dept. of Medical Biophysics, University of Toronto; R. Rottapel, Dept. of Medicine, University of Toronto, Princess Margaret Hospital, Ontario; R. Bristow, Dept. of Radiation Oncology and Div. of Experimental
Therapeutics, Princess Margaret Hospital,Toronto
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"" ... the book can be thoroughly recommended to anyone interested in the field." Trends in Cell Biology"
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Phosphatidylinositol 3-kinase signalling: a tale of two kinase activities
Mammalian MAP kinase pathways
Genetic approaches to protein kinase function in lower eukaryotes
Specificity in JAK-STAT signalling
On the road to destruction: suppression of protein tyrosine kinase
Cyclin-dependent protein kinases
Mechanisms and biology of signalling by serine/threonine kinase receptors form the TGFß superfamily
The ATM and DNA-PK proteins: The sensing, signaling and repair of DNA Damage
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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