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Molecular Epidemiology
Edited by Mary Carrington and Rus Hoelzel
264 pages
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numerous figures, tables and 5 halftones
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246x189mm
978-0-19-963811-6
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Hardback
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04 October 2001
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This item is printed to order. Items which are printed to order are normally despatched and charged within 5-10 days.
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- The Sequencing of the human genome has turned this into a rapidly growing area
- Covers all major molecular techniques and statistical methods of data analyses
The 'molecular' aspect of molecular epidemiology refers to the application of molecular biological approaches to epidemiologic problems. The variety and power of molecular methods are rapidly expanding our capability to dissect etiologic mechanisms of disease. The 'epidemiologic' aspect, meanwhile, refers to utilizing the tools and perspectives of epidemiology to comprehend observations in molecular biology. An increasingly sophisticated variety of molecular techniques are being applied to generate an explosion of data on exposures and outcomes whose significance must be determined.
The wealth of information
generated by the Human Genome Project and the corresponding efforts in microbial genomics are providing researchers with extraordinary new opportunities to further understand the etiology of disease. Molecular epidemiology is rapidly evolving through the application of more relevant markers of exposure and better identification of subgroups at increased risk of early disease processes and progression.
This volume provides a broad overview of the diverse approaches encompassed by this emerging discipline. Chapters 1-3 highlight concepts and methods at the forefront of studies of infectious diseases, and include a synopsis of general epidemiologic design and analysis, as well as current techniques for molecular typing of microbial pathogens. Chapters 4-6 are focussed
on recent advances in studying host genetics, including methods for the detection of mutations and polymorphisms, identification of linkage among alleles of genes on a given chromosome, and the use of DNA pooling to increase efficiency in association studies of genetically complex traits. Chapters 7 and 8 deal with the relationship between pathologies and immune system genetics, and on the use of DNA sequence information to garner insights into the evolution of infectious pathogens, and into the evolution and function of the immune system.Readership: Those working in molecular biology, epidemiology, human population genetics, clinical bacteriology and virology, public health
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Edited by Mary Carrington, National Cancer Institute, Frederick, Maryland, USA, and Rus Hoelzel, Department of Biological Sciences, University of Durham, UK Contributors:
Charles Rabkin, Nathaniel Rothman, Eric A Engels, Thomas R O'Brien, Eric W Brown, Shirley Kwok, Michael Dean, Bernard Gerrard, Rando Allikmets, Lisa F Barcellos, Soren Germer, William Klitz, Michael Cullen, Mary Carrington, Henry Erlich, Elizabeth A Trachtenberg, Austin L Hughes, Jack da Silva, Federica Verra.
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""Each chapter has been written with new researchers in mind, with an easily navigable layout and succinct definitions of specialist terms. The examples provided are presented well and the authors successfully avoid redundant statements, making the information accessible and easy to digest...Molecular Epidemiology was a delight to read and would be invaluable for an undergraduate module."" - Journal of Biological Education
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Charles Rabkin and Nathaniel Rothman: Introduction
1: Eric A Engels and Thomas R O'Brien: Epidemiological methods for studies of genetic factors that influence infectious diseases
2: Eric W.Brown: Molecular Differentiation of bacterial strains
3: Shirley Kwok: Detection and quantification of heterogeneous viral targets: using HIV as a model
4: Michael Dean, Bernard Gerrard and Rando Allikmets: Mutation Detection by Single-Stranded Conformation Polymorphism and Denaturing High Performance Liquid Chromatography
5: Lisa F.Barcellos, Soren Germer and William Klitz: DNA Pooling Methods for association mapping of complex disease loci
6: Michael Cullen and Mary Carrington: Single-sperm typing: a rapid alternative to family based linkage analysis
7: Henry A.Erlich and Elizabeth A.Trachtenberg: PCR-based methods of HLA typing
8: Austin L.Hughes, Jack da Silva and Federica Verra: Evolutionary Analysis of Molecular Sequence Data
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