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Frontiers in Nucleic Acids
Edited by Richard Sheardy and Stephen Winkle
200 pages
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227x152mm
978-0-84-122623-4
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Hardback
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24 May 2012
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- Presents the latest cutting edge research in nucleic acids
This book evolved from a symposium held at the Joint Southeast Southwest Regional meeting of the American Chemical Society in December, 2010 in New Orleans, LA. The symposium, hosted by the Division of Biological Chemistry, focused on the latest cutting edge research in nucleic acids. Although "Frontiers in Nucleic Acids" has always been a symposium at SERMACS meeting and at the five year joint meetings of the southwest and southeast regions, this represents the first time that the proceedings of the symposium have been published.
The first four chapters of the book
focus on the conformational properties of DNA quadruplexes: Prof. David uses SPR to monitor the inhibition of helicase activity on a DNA quadruplex; a facile fluorescence based assay for quadruplex DNA cleavage is presented in the next chapter by Prof. Kerwin; the structure, stability and ligand binding properties of DNA quadruplexes found in promoter regions of some oncogenes is discussed by Prof. Lewis; and the fourth chapter examines the influence of sequence context on the structure of DNA quadruplexes as presented by Prof. Sheardy. The next chapter, by Prof. Bishop, is an interesting computational tour de force examining nucleosomal DNA. Prof. Marky discusses the thermodynamics of unfolding DNA hairpins. Chapter 7, by Prof. Wartell, also considers thermodynamics but now for the
interactions of Hfq with RNA. The final three chapters deal with ligand-DNA interactions: Prof. Williams examines the interactions of proteins with the grooves of DNA; the irreversible binding of aflatoxin to DNA is examined by Prof. Stone; and the final chapter focuses on the interactions of restriction nucleases with various DNAs as presented by Prof. Winkle.Readership: Academics and professionals in related fields
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Edited by Richard Sheardy and Stephen Winkle Richard D. Sheardy, Department of Chemistry and Physics, Texas Woman's University
Stephen A. Winkle, Department of Chemistry and Biochemistry, Florida International University
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Preface
1. Inhibition of G-Quadruplex Helicase Activity As Determined by Surface Plasmon Resonance
Matthew Decker, Bhupendra Mishra, Dalip Kumar, and Wendi M. David
2. A Fluorescence-Based G-Quadruplex DNA Cleavage Assay
Michelle Schoonover and Sean M. Kerwin
3. Biophysical Studies of the Structure, Stability, and Ligand Binding Properties of G-Quadruplex DNA: Thoughts and Comparisons of the K-ras, c-MYC, and Bcl-2 Oncogene Promoter Sequence Quadruplexes
Jamie M. Dettler and Edwin A. Lewis
4. A CD Spectroscopic Investigation of Intermolecular and Intramolecular DNA Quadruplexes
Brenna A. Tucker, Sahmla Gabriel, and Richard D. Sheardy
5. Nucleosomal DNA: Kinked, Not Kinked, or Self-Healing Material?
Rajib Mukherjee and Thomas C. Bishop
6. The Size of Internal Loops Influences the Unfolding Thermodynamics of DNA Hairpins
Iztok Prislan, Hui-Ting Lee, Cynthia Lee, and Luis A. Marky
7. A Thermodynamic Perspective of sRNA-mRNA Interactions and the Role of Hfq
Kanav Jain, Taylor B. Updegrove, and Roger M. Wartell
8. Protein: Feeling the Groove of DNA
Derrick Watkins, Lydia-Ann Harris, Gerald B. Koudelka, and Loren Dean Williams
9. Chemistry and Biology of Aflatoxin-DNA Adducts
Michael P. Stone, Surajit Banerjee, Kyle L. Brown, and Martin Egli
10. Examining Flanking Sequence Specificity and Topological Specificity in the Binding of Various Molecular Types to DNAs Using Restriction Endonuclease Activity Assays
S. A. Winkle, E. Duran, J. Pulido, G. Santil, M. Talavera, C. Winkle, R. D. Sheardy, and V. Ramsauer
Editors' Biographies
Indexes
Author Index
Subject Index
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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