Actins are a highly conserved family of proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility - from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins families from myosins to gelsolins. This up-to-date edition gives a comprehensive account of actin sequence, mutation and structure as well as providing insight into ligand-binding sites and drug and toxin binding. Illustrated throughout, this modern text also contains an extensive bibliography for the interested reader.
Readership: Postgraduates and researchers in protein biochemistry and molecular
biology. Cell biologists and pharmacologists will also find this book useful.
Peter Sheterline, Department of Human Anatomy and Cell Biology, University of Liverpool, Jon Clayton, EMBL, and John C. Sparrow, Department of Biology, University of York
Biological characteristics of actin
Functional properties of actin
The actin sequence
Molecular genetic manipulation of actin
Covalent derivation sites
Post-translational modificaiton sites
Proteolytic cleavage sites
Drug and toxin binding
Protein Sequence Alignments