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Readership: Upper level undergraduates and beginning graduates following a range of bioscience-related programmes of study.
Philip Meneely, Department of Biology, Haverford College, PA, USA
"'It is refreshing to see the focus move away from the detail of molecular mechanism towards understanding and scientific investigation' The Society for General Microbiology"
"'Philip Meneely makes a concerted effort to tie the key concepts derived from model systems to an understanding of human medical genetics, which works well and will be appreciated by students.' The Society for General Microbiolo gy"
"I enjoyed reading this chapter with its wonderful analogies...The author is gifted in writing in such a way that the reader will understand difficult concepts." - Helena Kuivaniemi, Center for Molecular Medicine and Genetics, Wayne State University, USA
Unit 1 Genes and Genomes
1: The logic of genetic analysis
2: Model organisms and their genomes
Unit 2 Genes and Mutants
3: Identifying mutants
4: Classifying mutants
5: Connecting a phenotype to a DNA sequence
6: Finding mutant phenotypes for cloned genes
7: Genome-wide mutant screens
Unit 3. Gene Activity
8: Molecular analysis of gene expression
9: Analysis of gene activity using mutants
Unit 4. Gene Interactions
10: Using one gene to find more genes
11: Epistasis and genetic pathways
12: Pathways, networks, and systems