Juvenile Huntington's Disease

• Focuses on the clinical features, diagnosis, assessment and therapy to assist clinicians working with families affected by JHD and HD
• Sections cover psychosocial, clinical and scientific aspects of the condition to create a complete reference guide in one volume

Readership: Paediatric neurologists, neurologists, geneticists, research scientists and those caring for young people with juvenile Huntington's Disease.

Edited by Oliver W.J. Quarrell, Consultant in Clinical Genetics at Sheffield Children's Hospital, and Vice-Chair of the Huntington's Disease Association, UK, Helen M. Brewer, Care Adviser - Juvenile Huntington's Disease, Huntington's Disease Association, England and Wales, UK, Ferdinando Squitieri, Director of the Neurogenetics Unit, IRCCS Neuromed and Centre for Rare diseases, Pozzilli, Italy, Roger A. Barker, Reader in Clinical Neuroscience and Honorary Consultant Neurologist, University of Cambridge and Addenbrooke's Hospital, UK, Martha A. Nance, Medical Director of the HDSA Center of Excellence, Hennepin County Medical Center, Minneapolis, USA and Adjunct Professor in the Department of Neurology at the University of Minnesota, USA, and G. Bernhard Landwehrmeyer, Professor of Neurology at the University of Ulm, Germany and Chief Executive of the European Huntington's Disease Network

1: Helen Brewer and Marie McGill: Family experiences: Part I diagnosis and early stages
2: Helen Brewer & Marie McGill: Family experiences: Part II later stages
3: Raymund A.C. Roos: The history of Juvenile Huntington's disease
4: Roger A. Barker and Ferdinando Squitieri: The clinical phenotype of JHD
5: Jean Paul G. Vonsattel, Etty P. Cortes and Christian E. Keller: Juvenile Huntington disease neuropathology
6: Roman Gonitel and Ferdinando Squitieri: Molecular mechanisms in Juvenile Huntington's disease
7: Gill Bates and Ben Woodman: Juvenile HD and Mouse models of Huntington's disease
8: André R. Troiano and Alexandra Dürr: Clinical features of early and juvenile onset in polyglutamine disorders other than HD: autosomal dominant cerebellar ataxias and dentatorubral pallidoluysian atrophy
9: Oliver Quarrell & Martha Nance: The diagnostic challenge
10: Martha Nance: Current therapeutic options
11: Helen Brewer and Aimee Aubeeluck: Psychosocial issues surrounding JHD
12: Helen Brewer, Roger Barker and Oliver Quarrell: Challenges in assessment
13: Appendix 1 - JHD Total Functional Capacity
14: Appendix 2 - JHD Functional Assessment
15: Appendix 3 - JHD Motor Scale