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Huntington's Disease
Third Edition
Edited by Gillian Bates, Peter Harper, and Lesley Jones
574 pages
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numerous figures, tables and black and white photographs
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240x168mm
978-0-19-851060-4
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Hardback
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03 October 2002
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- Radically updated to include coverage of developments in the molecular biology and genetics of the condition following isolation of the gene
- Includes implications for prediction and genetic counselling as well as therapy
- Well-established new edition edited by the leading international experts in the field
It is now almost a decade since the identification of the Huntington's Disease gene and its mutation, during which time, major advances in our understanding of this disorder have been achieved. Since publication of the first two editions of this book, there have been considerable insights into how the mutation leads to the molecular pathology, neuropathology and clinical symptoms of Huntington's Disease, and experimental tools are now in place to take this research further towards new therapeutic approaches. As a result of these major advances, this well-established series of books has required radical updating.
An international group of researchers and clinicians with specialist interests in HD has been commissioned to document the recent advances in our understanding of this disease. Developments in the fields of structural biology, cell biology, neurochemistry and neuropathology, with full coverage of transgenic animal models, are discussed in detail. The clinical sections cover genetic, neurological and psychiatric aspects as well as new developments in therapy.
This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists, and basic science research workers in genetics and
neurobiology.Readership: Clinicians and scientists involved with HD including geneticists, psychiatrists and neurologists and basic research workers (genetics, neurobiology).
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Edited by Gillian Bates, Professor of Neurogenetics, Division of Medical and Molecular Genetics, GKT School of Medicine, King's College, Guy's Hospital, London, UK, Peter Harper, Professor of Medical Genetics and Consultant Physician, Institute of Medical Genetics, University Hospital of Wales College of Medicine, Heath Park, Cardiff, UK, and Lesley Jones, Senior Lecturer in Neuropsychiatric Genetics, Institute of Medical Genetics, and Department of Psychological Medicine, University of Wales College of Medicine, Health Park, Cardiff, UK Contributors:
Dr Thomasin Andrews, MRC Clinical Sciences Centre,
Imperial College School of Medicine, London, UK
Professor Gillian P. Bates, Division of Medical and Molecular Genetics, GKT School of Medicine, Guy's Hospital, London, UK
Caroline Benn, Neurogenetics Laboratory, Division of Medical and Molecular Genetics, GKT School of Medicine, Guy's Hospital, London, UK
Professor David Brooks, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Professor Jang-Ho J. Cha, Harvard Medical School Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Dr David Craufurd, Academic Unit of Medical Genetics and Regional Genetic Service, St Mary's Hospital, Manchester, UK
Dr Anja Dröge,
Department of Neuroproteomics, Max-Delbrueck-Centre for Molecular Medicine, Berlin, Germany
Professor Stephen Dunnett, Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK
Dr Claire-Anne Gutekunst, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
Professor Peter Harper, Consultant Physician and Consultant in Medical Genetics, Institute of Medical Genetics, University of Wales College of Medicine and University Hospital of Wales, Cardiff, UK
Dr Steven M Hersch, Department of Neurology, Harvard Medical School Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Dr Lesley Jones, Institute of Medical Genetics and
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
Professor Karl Kieburtz, University of Rochester, New York, USA
Professor Berry Kremer, Department of Neurology, University of Nijmegen, The Netherlands
Dr Kerry P.S.J. Murphy, Department of Biological Sciences, The Open University, Milton Keynes, UK
Dr Martha Nance, Hennepin County Medical Center, Minneapolis, USA
Dr Francine Norflus, Department of Neurology, Harvard Medical School Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, CHarlestown, Massachusetts, USA
Dr Anne Rosser, Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK
Professor Anthony H.V. Schapira,
University Department of Clinical Neurosciences, Royal Free and University College Medical School and Institute of Neurology, University College London, UK
Dr Ira Shoulson, University of Rochester, New York, USA
Dr Julie Snowden, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford, UK
Professor Aad Tibben, Departments of Clinical Genetics and Neurology, University of Lieden, The Nethelandsl Dr C. Turner, University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, UK Professor Erich E Wanker, Department of Neuroproteomics, Max-Delbrueck-Centre for Molecular Medicine, Berlin, Germany
Beryl Westphal, Hennepin County Medical Center, Minneapolis, USA
Dr George J. Yohrling, Harvard Medical School Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, Massachusetts, USA
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"It should be an essential part of the library of all neurology and genetic departments . . . it is so clearly written that it can be recommended to families affected by HD who have a desire to know as much as possible about the condition." - Journal of Neuromuscular Disorders ". . . the third edition of Huntington's Disease is a goldmine . . . Everyone who studies HD should own and read this book, and - to the extent that HD continues to provide a model and a benchmark - so should anyone interested in human genetic disorders" - Human Genetics, 114
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Section 1 - Clinical aspects of Huntington's disease
1: Harper: Huntington's disease: a historical background
2: Kremer: Clinical neurology of Huntington's disease
3: Craufurd & Snowden: Neuropsychological and neuropsychiatric aspects of Huntington's disease
4: Brooks & Andrews: Imaging Huntington's disease
Section 2 - The genetics of Huntington's disease
5: Harper & Jones: Huntington's disease: genetic and molecular studies
6: Harper: The epidemiology of Huntington's disease
7: Tibben: Genetic counselling and presymptomatic testing
Section 3 - Neurobiology
8: Gutekunst, Norflus & Hersch: The neuropathology of Huntington's disease
9: Yohrling & Cha: Neurochemistry of Huntington's disease
10: Turner & Schapira: Energy metabolism and Huntington's disease
Section 4 - Molecular biology and Huntington's disease
11: Wanker & Dröge: Structural biology of Huntington's disease
12: Jones: The cell biology of Huntington's disease
13: Bates & Murphy: Mouse models of Huntington's disease
Section 5 - Other polyglutamine diseases
14: Bates & Benn: The polyglutamine disease
Section 6 - Therapeutic Interventions
15: Nance & Westphal: Comprehensive care in Huntington's disease
16: Kieburtz & Shoulson: Therapeutic trials in Huntington's disease
17: Dunnett & Rosser: Cell and tissue transplantation
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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