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DNA Topology
Andrew D. Bates and Anthony Maxwell
216 pages
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numerous line drawings and halftones
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234x156mm
978-0-19-856709-7
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Hardback
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10 February 2005
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- Comprehensive but concise overview of DNA structure and function
- Clear and accessible explanation of complex topological concepts
- Describes the biological significance of the topological aspects of DNA structure
- Accompanying website provides ancillary material
DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated. However, it has become clear that there are many deviations from this basic structure that have important biological consequences. Prominent among these are the 'topological' configurations: supercoiling, knotting, and catenation (linking). Unfortunately, a full understanding of these features of DNA structure requires the grasp of concepts that can prove difficult for both students
and more advanced researchers. This book aims to explain these ideas simply, but rigorously, to allow a wider appreciation of DNA topology.
DNA Topology starts with a basic account of DNA structure before going on to cover DNA supercoiling, the definitions and physical meanings of linking number, twist, and writhe, and the free energy associated with supercoiling. It then considers the rather more complex description of DNA lying on a curved surface and its application to the nucleosome, followed by the phenomena of DNA knotting and catenation. The final chapters deal with the topoisomerases, the enzymes that control DNA topology, and, most importantly, with the biological significance of the topological aspects of DNA structure. Although some of these concepts
are quite complex, they are presented in an accessible way, drawing on interesting and relevant examples.Readership: Students and researchers of DNA topology, molecular biology, biochemistry and genetics.
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"DNA Topology provides a solid basis for understanding the physical properties of DNA and its topology, and how this molecule actively participates in many cellular processes. This book is certainly aimed at specialists, whom it will not diappoint with its detailed treatment of the core subject matter." - The Quarterly Review of Biology, Volume 81, March 2006.
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1: DNA structure
2: DNA supercoiling
3: DNA on surfaces
4: Knots and catenanes
5: DNA topoisomerases
6: Biological consequences of DNA topology
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