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Embryonic Stem Cells
A Practical Approach
Edited by Elena Notarianni and Martin J. Evans
360 pages
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16 colour plates, 31 halftones, numerous tables and line drawings
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246x189mm
978-0-19-855001-3
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Paperback
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04 May 2006
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- Co-edited and introduced by the originator of embryonic stem cell research, this book provides a unique perspective on the field by this most influential of pioneers into ES cell research.
- Integrated approach to ES cell biology, dealing with mouse and primate cells in one volume.
- Compendium of detailed methods for the derivation and manipulation of ES cells, from acknowledged experts in the field. Provides ample details and trouble shooting tips to ensure reproducibility of experimental protocols.
- Covers emergent applications of ES cell research (e.g. research into mitochondrial disease, cloning etc.), as well as established areas (differentiation of ES cells into desired cell types) and thus gives a full range of the potential uses of ES cells.
The groundbreaking isolation of embryonic stem cells (or 'ES cells') of the mouse in the early 1980s triggered a sustained expansion of global research into their exploitation. This led to the routine genetic engineering of the mouse and revolutionised our understanding of biological processes in the context of the whole animal. ES cell biology remains a crucial and growing area of research with far-reaching implications for developmental and comparative biology as
well as for human health.
This book serves as a primer to ES cells, their derivation and experimental manipulation. It contains a broad compendium of methods of direct relevance to both graduate students and specialist researchers. An introductory chapter by the principle originator of ES cell research outlines the fundamentals and charts the development of the field. This is followed by comprehensive coverage of state-of-the art techniques for ES cell manipulation, with the mouse as the experimental paradigm, and by recent innovations with ES cells from human and non-human primates. ES cell-based therapies for otherwise intractable diseases are now being developed with the present challenge to control ES cell growth and differentiation for applications such as cell
transplantation - a recurrent theme in this book. As a volume in the Practical Approach Series, the emphasis is on current methods from recognised experts.Readership: Graduates in cell biology.
Specialist researchers into ES cell biology.
Clinical researchers.
Pharmacologists.
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Edited by Elena Notarianni, Comparative Biology Centre, The Medical School, University of Newcastle, and Martin J. Evans, Director, Cardiff School of Biosciences, Cardiff University Contributors:
Martin J Evans (Cardiff School of Biosciences, University of Cardiff, Cardiff, UK)
Frances A Brook (Deptartment of Zoology, University of Oxford, Oxford, UK)
Yoko Kato (Laboratory of Animal Reproduction, College of Agriculture, Nara, Japan)
Yukio Tsunoda (Laboratory of Animal Reproduction, College of Agriculture, Nara, Japan)
Grant R. MacGregor (Center for Molecular and Mitochondrial
Medicine and Genetics, University of California, Irvine, USA)
Wei Wei Fan (Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, USA)
Katrina G. Waymire (Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, USA)
Douglas C. Wallace (Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, USA)
Michael V. Wiles (The Jackson Laboratory, Maine, USA)
Gabriele Proetzel (Scil Proteins, Halle, Germany)
Yelena S. Tarasova (Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, USA)
Daniel R. Riordon (Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore,
USA)
Kirill V. Tarasov (Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, USA)
Kenneth R. Boheler (Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, USA)
Osamu Ohneda (Department of Regenerative Medicine, University of Tsukuba, Tsukuba, Japan)
Masayuki Yamamoto (Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan)
Tanja Schmandt (Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany)
Tamara Glaser (Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany)
Oliver Brüstle (Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany)
Przemyslaw Blyszczuk
(Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany)
Gabriela Kania (Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany)
Anna M. Wobus (Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany)
Martin F. Pera (Monash Institute of Medical Research, Monash University, Clayton Victoria, Australia)
Andrew Laslett (Monash Institute of Medical Research, Monash University, Clayton Victoria, Australia)
Susan M. Hawes (Monash Institute of Medical Research, Monash University, Clayton Victoria, Australia)
Irene Tellis (Monash Institute of Medical Research, Monash University, Clayton Victoria, Australia)
Karen Koh (Monash Institute of Medical Research, Monash
University, Clayton Victoria, Australia)
Lihn Nguyen (Monash Institute of Medical Research, Monash University, Clayton Victoria, Australia)
Sharon Gerecht-Nir (Massachusetts Institute of Technology, Cambridge, USA)
Joseph Itskovitz-Eldor (Technion-Israel Institute of Technology, Haifa, Israel)
Hirofumi Suemori (Institute for Frontier Medical Sciences, Kyoto University, Kyoto , Japan)
Yoshiki Sasai (RIKEN Center for Developmental Biology, Kobe, Japan)
Katsutsugu Umeda (Department of Pediatrics, Kyoto University, Kyoto , Japan)
Norio Nakatsuji (Institute for Frontier Medical Sciences, Kyoto University, Kyoto , Japan)
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Preface
1: Martin J Evans: Introduction
2: Frances A. Brook: Procedures for deriving ES cell lines from the mouse
3: Yoko Kato and Yukio Tsunoda: Production of ES cell-derived mice
4: Grant R. MacGregor, Wei Wei Fan, Katrina G. Waymire, and Douglas C. Wallace: Generating animal models of human mitochondrial genetic disease using mouse ES cells
5: Michael V. Wiles and Gabriele Proetzel: Controlling the differentiation of mouse ES cells in vitro
6: Yelena S. Tarasova, Daniel R. Riordon, Kirill V. Tarasov and Kenneth R. Boheler: In vitro differentiation of mouse ES cells into muscle cells
7: Osamu Ohneda and Masayuki Yamamoto: In vitro differentiation of mouse ES cells into haematopoietic cells
8: Tanja Schmandt, Tamara Glaser and Oliver Brüstle: Lineage selection and transplantation of mouse ES cell-derived neural precursors
9: Przemyslaw Blyszczuk, Gabriela Kania and Anna M. Wobus: In vitro differentiation of mouse ES cells into pancreatic and hepatic cells
10: Martin F. Pera, Andrew Laslett, Susan M. Hawes, Irene Tellis, Karen Koh, and Lihn Nguyen: Isolation and characterisation of human ES cells
11: Sharon Gerecht-Nir and Joseph Itskovitz-Eldor: Differentiation of human ES cells
12: Hirofumi Suemori, Yoshiki Sasai, Katsutsugu Umeda and Norio Nakatsuji: ES cell lines from the cynomolgus monkey (Macaca fascicularis)
Index
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Scientific and Regulatory Issues
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The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.
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