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Apoptosis
A Practical Approach
Edited by George Studzinski
266 pages
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2 colour, 10 halftone, and 29 line illustrations
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234x156mm
978-0-19-963785-0
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Paperback
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09 December 1999
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This item is printed to order and supplied on a firm sale basis. Items which are printed to order are normally despatched and charged within 5-10 days.
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- Easy to follow with an accessible approach
- Provides background for interpretation
- Suggests novel ideas
- Nearly 70 protocols
- Well illustrated; some colour figures
This text is designed to provide conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptosis. Chapters on the recognition of apoptosis as distinguished from necrosis and nonspecific cell DNA damage, are followed by a systematic examination of the established and the principal novel methodologies utilized by some leading laboratories conducting research on apoptosis. The organization is on the lines of signalling for apoptosis, the apoptotic cascade, and the execution of apoptosis. A wide variety of procedures are provided which will enable the reader to participate in cutting-edge
research.Readership: Main: Cancer researchers and developmental biologists. Other: All biomedical researchers.
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Edited by George Studzinski, Professor of Pathology and Laboratory Medicine, New Jersey Medical School Contributors:
George P. Studzinski, Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 S. Orange Avenue, University Heights, Newark, N.J. 07103, USA; James W. Wilson, CRC Epithelial Biology Laboratory, Section of Cell and Tumor Biology, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester, M20 4BX, UK; Christopher S. Potten, CRC Epithelial Biology Laboratory, Section of Cell and Tumor Biology, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester, M20 4BX, UK;
Akira Yoshida, Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA; Rong-Guang Shao, Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA; Yves Pommier, Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA; Zbigniew Darzynkiewicz, Brander Cancer Research Institute, NYMC 19 Bradhurst Avenue, Hawthhorne, N.Y. 10532, USA; Elzbieta Bedner, Brander Cancer Research Institute, NYMC 19 Bradhurst Avenue, Hawthhorne, N.Y. 10532, USA; Xun Li, Brander Cancer Research Institute, NYMC 19 Bradhurst Avenue, Hawthhorne, N.Y.
10532, USA; Javier Naval, Dept. Bioquimica y Biologia Molecular y Celular, Faculty of Sciences, University of Zaragoza, Zaragoza, 50009, Spain; Alberto Anel, Dept. Bioquimica y Biologia Molecular y Celular, Faculty of Sciences, University of Zaragoza, Zaragoza, 50009, Spain; Gary M. Jenkins, 114 Doughty St, Rom. 611, Strom Thurmond Bldg, Charleston, SC 29425, USA; Yusuf A. Hannun, 114 Doughty St, Rom. 611, Strom Thurmond Bldg, Charleston, SC 29425, USA; Manon van Engeland, Department of Molecular Cell Biology & Genetics, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands; Bert Schutte, Department of Molecular Cell Biology & Genetics, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands; Anton H.M. Hopman, Department of Molecular Cell Biology &
Genetics, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands; Frans C.S. Ramaekers, Department of Molecular Cell Biology & Genetics, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands; Chris P.M. Reutelingsperger, Department of Biochemistry, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands; Ana P. Costa-Pereira, Tumour Biology Laboratory, Department of Biochemistry, University College, Cork, Ireland; Thomas G. Cotter, Tumour Biology Laboratory, Department of Biochemistry, University College, Cork, Ireland; John C. Reed, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Zhihua Xie, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Shinichi Kitada, The Burnham
Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Juan M. Zapata, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Qunli Xu, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Sharon Schendel, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Maryla Krajewska, The Burnahm Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; Stanislaw Krajewski, The Burnahm Institute, 10901 North Torrey Pines Road, La Jolla, CA 93037, USA; April L. Blajeski, Department of Pharmacology, Mayo Graduate School, Rochester, MN 55905, USA; Scott H. Kaufmann, Guggenheim 1342C, Mayo Clinic, 200 First St., S.W. Rochester, MN 55905, USA
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""The major strength of this book is the wealth of apaptosis-associated protocols provided by the authors ... a significant addition to the apaptosis literature and particularly valuable for mammalian cell biologists" Trends in Cell Biology"
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Preface
1: Studzinski: Overview of Apoptosis
2: Wilson and Potten: The Morphological Recognition of Apoptosis
3: Yoshida, Shao and Pommier: Assessment of DNA Damage in Apoptosis
4: Darzynkiewicz, Bedner and Li: Analysis of Cell Death by Flow and Laser Scanning Cytometry
5: Naval and Anel: Cell-mediated Cytotoxicity and Cell Death Receptors
6: Jenkins and Hannun: Sphingolipids as Messengers of Cell Death
7: Van Engeland et al: Cytochemical Detection of Cyto- and Nucleoskeletal Changes During Apoptosis
8: Costa-Pereira and Cotter:
9: Reed et al: Methods of Measuring Bcl-2 Family Proteins and Their Functions
10: Blajeski and Kaufmann: Methods for Detecting Proteolysis During Apoptosis in Intact Cells
Index
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